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Brackett was born in Saratoga Springs, New York, the son of Mary Emma Corliss and New York State Senator, lawyer, and banker Edgar Truman Brackett. The family's roots traced back to the arrival of Richard Brackett in the Massachusetts Bay Colony in 1629, near present-day Springfield, Massachusetts. His mother's uncle, George Henry Corliss, built the Centennial Engine that powered the 1876 Centennial Exposition in Philadelphia. A 1915 graduate of Williams College, he earned his law degree from Harvard University. He joined the Allied Expeditionary Force during World War I. He was awarded the French Medal of Honor. He was a frequent contributor to the Saturday Evening Post, Collier's, and Vanity Fair, and a drama critic for The New Yorker. He wrote five novels: The Counsel of the Ungodly (1920), Week-End (1925), That Last Infirmity (1926), and American Colony (1929). and Entirely Surrounded (1934).

Brackett was a president of the Screen Writers Guild (1938–1939) and the Academy of Motion Picture Arts and Sciences (1949–1955). He either wrote and/or produced over forty films, including To Each His Own, Ninotchka, The Major and the Minor, The Mating Season (1951), Niagara, The King and I, Ten North Frederick, The Remarkable Mr. Pennypacker, and Blue Denim.

Beginning in August 1936, Brackett worked with Billy Wilder, writing the film classics The Lost Weekend and Sunset Boulevard, both of which won Academy Awards for their respective screenplays. Brackett described their collaboration process as follows: "The thing to do was suggest an idea, have it torn apart and despised. In a few days, it would be apt to turn up, slightly changed, as Wilder's idea. Once I got adjusted to that way of working, our lives were simpler."

His partnership with Wilder ended in 1950 and Brackett went to work at 20th Century-Fox as a screenwriter and producer. His script for Titanic (1953) won him another Academy Award.

He received an Honorary Oscar for Lifetime Achievement in 1958.

Charles Brackett died on March 9, 1969. His diaries covering his screenwriting and social life from 1932 to 1949 were edited by Anthony Slide into Slide's book It's the Pictures That Got Small: Charles Brackett on Billy Wilder and Hollywood's Golden Age.