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He has spent much of his theatre career working in productions for both the Royal Shakespeare Company and National Theatre. He has received ten Laurence Olivier Award nominations, winning three awards for his performances in Volpone (1996), Candide (2000), and Uncle Vanya (2003). For his work on the Broadway stage he has received a Tony Award for Best Actor in a Play nomination for his performance as George in the Tom Stoppard play Jumpers in 2004. For his role as Henry Lehman in The Lehman Trilogy, he won the Tony Award for Best Actor in a Play and was nominated for an Olivier Award. Beale has been described by The Independent as "the greatest stage actor of his generation".

Beale made his film debut in Sally Potter's period drama Orlando (1992). He continued acting in films such as Persuasion (1995), Hamlet (1996), My Week with Marilyn (2011), The Deep Blue Sea (2011), Into the Woods (2014), and Mary Queen of Scots (2018). In 2017, he starred in Armando Iannucci's dark comedy The Death of Stalin playing Lavrentiy Beria for which he received the British Independent Film Award for Best Supporting Actor. He has also appeared in the television projects The Young Visiters (2003), Dunkirk (2004), and as Falstaff in the BBC made-for-television films Henry IV, Part I and Part II (2012). He was part of the main cast of Showtime's Penny Dreadful.