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Hurt earned his third competitive BAFTA, along with his second Oscar and Golden Globe nominations, as Joseph Merrick in David Lynch's biopic The Elephant Man (1980). Other significant roles during the 1980s included Bob Champion in biopic Champions (1984), Mr. Braddock in the Stephen Frears drama The Hit (1984), Winston Smith in Nineteen Eighty-Four (1984) and Stephen Ward in the drama depicting the Profumo affair, Scandal (1989). Hurt was again BAFTA-nominated for his work in Irish drama The Field (1990) and played the primary villain, James Graham, in the epic adventure Rob Roy (1995). His later films include the Harry Potter film series (2001–11), the Hellboy films (2004 and 2008), supernatural thriller The Skeleton Key (2005), western The Proposition (2005), political thriller V for Vendetta (2005), action adventure Indiana Jones and the Kingdom of the Crystal Skull (2008), sci-fi action Outlander (2008) and the Cold War espionage film Tinker Tailor Soldier Spy (2011). Hurt reprised his role as Quentin Crisp in An Englishman in New York (2009), which brought his seventh BAFTA nomination. He portrayed the War Doctor in the BBC TV series Doctor Who's 50th anniversary special, "The Day of the Doctor", in 2013.

Hurt was regarded as one of Britain's finest actors; director David Lynch described him as "simply the greatest actor in the world". He possessed what was described as the "most distinctive voice in Britain", likened by The Observer to "nicotine sieved through dirty, moonlit gravel". His voice acting career encompassed films such as Watership Down (1978), The Lord of the Rings (1978), The Plague Dogs (1982), The Black Cauldron (1985), Dogville (2003) and Planet Dinosaur (2011) as well as BBC TV series Merlin (2008–2012). In 2012, he was honoured with the Lifetime Achievement BAFTA Award, in recognition of his "outstanding contribution to cinema". He was knighted in 2015 for his services to drama.