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She began her career as a teenage actress by appearing in the Broadway musical 13 (2008). She rose to fame as Cat Valentine in the Nickelodeon television series Victorious (2010–2013) and its spin-off series Sam & Cat (2013–2014). Grande signed with Republic Records and released her retro-pop and R&B-influenced debut studio album, Yours Truly (2013), which debuted at number one on the Billboard 200. She blended pop, R&B, and electronic on her second and third albums, My Everything (2014) and Dangerous Woman (2016), which both achieved international success and contained the singles "Problem", "Break Free", "Bang Bang", "One Last Time", "Into You" and "Side to Side".

Personal struggles influenced Grande's trap-infused albums Sweetener (2018) and Thank U, Next (2019). The former won Grande her first Grammy award, while the latter garnered US number-one singles "Thank U, Next" and "7 Rings", and made her the first solo artist to occupy the top three spots of the Billboard Hot 100. She subsequently achieved the most number-one debuts in Hot 100 chart history with the title track of her sixth album, Positions (2020), as well as the collaborations "Stuck with U" and "Rain on Me". After a musical hiatus, Grande released her seventh album, Eternal Sunshine (2024), which yielded the US number-one singles "Yes, And?" and "We Can't Be Friends (Wait for Your Love)". She returned to film acting with the political satire Don't Look Up (2021) and received critical praise for her portrayal of Glinda in the fantasy musical Wicked (2024), earning her a nomination for the Academy Award for Best Supporting Actress.