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Apted began working in television and directed the Up documentary series from 1970 to 2019. He later directed Coal Miner's Daughter (1980), which was nominated for seven Academy Awards, including Best Picture. His subsequent work included Gorillas in the Mist (1988), Nell (1994), the James Bond film The World Is Not Enough (1999), and Enigma (2001). His film Amazing Grace (2006) premiered at the Toronto International Film Festival that year.

On 29 June 2003, he was elected president of the Directors Guild of America, a position he served until 2009. He was appointed Companion of the Order of St Michael and St George (CMG) in the 2008 Birthday Honours.